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How does fertilization occur?

Each month, a mature egg is released. Fertilization happens when it meets a sperm cell: the two fuse, and their chromosomes combine into a zygote.

1 min read

Each month, a woman naturally produces a mature oocyte from a pre-ovulatory follicle, which is then ovulated. Fertilization occurs when this oocyte meets a sperm cell. It involves highly complex interactions, requiring the maturation of sperm in the female reproductive tract and the ability of the mature oocyte to recognize and bind with the sperm, allowing fusion.

Once the sperm has penetrated the oocyte, two pronuclei quickly appear—the female pronucleus and the male pronucleus, each containing the chromosomal material from both individuals. The recognition and fusion of maternal and paternal chromosomes result in the formation of the zygote, the first stage of embryonic development.

General information, not a diagnosis: talk to your doctor about your own situation.

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Written by

  • Prof. Arash Rafii

    Professor of Obstetrics, Gynecology and Genetic Medicine

    Sidra Hospital

  • Prof. Michaël Grynberg

    Professor of Reproductive Medicine, Obstetrics and Gynecology

    Antoine Béclère and Jean Verdier University Hospitals

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